If you need to lock folders on a USB drive, hide private files, or carry encrypted data between Windows PCs, the best choice depends on whether you need selected-folder control or whole-drive encryption.
1. You mainly want to lock or hide selected folders on a USB drive.
2. You need password workflows, read-only mode, monitoring, or shared-folder style controls.
3. You want portable encryption for files that may be opened on other Windows computers.
Your main goal is encrypting the whole removable drive rather than managing only selected folders. That workflow is often a better fit when the entire USB device carries sensitive content from end to end.
For most users searching "best file locker for USB drive," GiliSoft File Lock Pro is the better match because the query usually means folder locking, hide mode, and access control. If you need whole-drive security, GiliSoft USB Encryption is the stronger alternative.